|
Materia’s olefin metathesis catalyst technology represents the most innovative and significant method by which olefin substrates can be redistributed to yield a net exchange of the substituents. This powerful methodology is facilitated by a reaction between a selected catalyst (blue) and an olefin substrate (red). The reaction proceeds via the reversible formation of a 4-membered metallacycle intermediate (in brackets).
The cyclo-reversion of the metallacycle can reform the starting materials, or productive cleavage forms a new carbon-carbon double bond and a new metal-carbene capable of propagating through the reaction pathway; an overall cross metathesis reaction.
While olefin metathesis reactions are fundamentally significant to reformation processes in the petrochemical industry, the pharmaceutical industry utilizes olefin metathesis methodologies in pursuit of complex active pharmaceutical ingredients. The added value of Materia’s catalyst technology stems from the ability to facilitate numerous olefin metathesis transformations including:
Ring Closing Metathesis (RCM)
Cross Metathesis (CM)
Ring Opening Metathesis Polymerization (ROMP)
Acyclic Diene Metathesis Polymerization (ADMET)
These reaction profiles enable the wide range of applications and production in fine chemical, pharmaceutical, agrochemical, pheromone, fragrance, polymer, and high performance material industries. Materia provides and employs a large library of olefin metathesis catalysts to facilitate the technology described above.
For additional information on olefin metathesis visit http://allthingsmetathesis.com.
|
